The following is an excerpt....
BASICS
Description
- Stevens-Johnson Syndrome (SJS) is a severe hypersensitivity reaction, characterized by diffuse bullous lesions, mucocutaneous involvement, and marked constitutional symptoms.
- SJS is often considered to lie on a spectrum between erythema multiforme minor (EM minor) on 1 extreme, and toxic epidermal necrolysis (TEN) on the other, but this classification is controversial. In this schema, SJS is defined as involving >2 mucous membranes and <10% of total body surface area, and TEN as involving >30%, with overlap in between.
Epidemiology
Affects all ages, ethnicities, and both genders equally
Incidence
Incidence is 2–3 cases per million people each year.
Pathophysiology
- SJS is an acute hypersensitivity reaction, characterized by a cell-mediated immunologic reaction.
- A prodrome of 1–14 days is often seen, consisting of constitutional symptoms, including high fever ...
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