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Transverse Myelitis Updated 4/2010

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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • Pathophysiology
  • Etiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis
  • Medication (Drugs)
  • Interventional
  • Rehabilitation

Follow-up

  • Prognosis
The following is an excerpt....
BASICS
Description
  • Transverse myelitis (TM) is a focal inflammatory process of the spinal cord with subsequent and variable motor, sensory, and autonomic dysfunction attributable to spinal cord pathology.
  • Myelitis refers to spinal cord inflammation, whereas transverse refers to involvement across one level of the cord.
  • System(s) affected:
    • –Nervous
    • –Immune
Epidemiology
Incidence

One to eight new cases per million per year.

Prevalence

All ages may be affected:

  • Bimodal peaks between 10 and 19 years and 30 and 39 years
Risk Factors
Genetics

No familial or gender predisposition

Pathophysiology
  • In acute TM associated with systemic disease, a spinal cord vasculitic or granulomatous process may be seen.
  • Degradation of the blood–brain barrier with spinal cord cellular influx, neuronal injury, and demyelination ...

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