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Barbiturates Poisoning Updated 12/2010

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BASICS

  • Description
  • Etiology

DIAGNOSIS

  • Signs and Symptoms
  • Essential Workup
  • Tests
  • Differential Diagnosis

TREATMENT

  • Pre-hospital
  • Initial Stabilization
  • ED Treatment
  • Medication (Drugs)
  • In-patient Considerations

Ongoing Care

  • Follow-Up Recommendations
The following is an excerpt....
BASICS
Description
  • Class of sedative–hypnotic agents
  • Derivatives of barbituric acid
  • Mechanism:
    • Enhances activity of g-aminobutyric acid (GABA)
    • At high levels, directly opens GABA-A associated chloride channel
    • Leads to inhibition of vascular smooth muscle tone
    • May lead to direct myocardial depression
Etiology

Overdose of barbiturates:

  • Intentional or nonintentional

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