The following is an excerpt....
BASICS
Description
- Dengue fever occurs secondary to dengue viral infection.
- Poorly understood immunopathologic response causes dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS).
- DHF and DSS usually occur in patients with previous exposure to dengue virus.
- Hemorrhagic manifestations occur after defervescence of fever.
- Vascular permeability increases.
- Plasma extravasates into extravascular space, including pleural and abdominal cavities.
- Bleeding tendency
- Shock may ensue.
- Disseminated intravascular coagulation (DIC) may develop.
- Dengue fever, DHF, and DSS are all self-limited.
- World Health Organization—required criteria for diagnosis of DHF:
- Fever
- Bleeding evidenced by one of the following: Positive tourniquet test petechia, ecchymosis, purpura, GI tract bleeding, injection site bleeding
- Increased vascular permeability and plasma leakage as evidenced by an elevated hematocrit (>20%), decreased ...
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