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Toluene Poisoning Updated 12/2010

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BASICS

  • Description
  • Etiology

DIAGNOSIS

  • Signs and Symptoms
  • Essential Workup
  • Tests
  • Differential Diagnosis

TREATMENT

  • Pre-hospital
  • Initial Stabilization
  • ED Treatment
  • Medication (Drugs)
  • In-patient Considerations

Ongoing Care

  • Follow-Up Recommendations
The following is an excerpt....
BASICS
Description

Volatile hydrocarbon

Etiology
  • Abused for its euphoric effect
  • Occupational exposures
  • Used as organic solvent found in:
    • Oil paints and stains
    • Paint thinners
    • Glues, inks, dyes
    • Coolants
    • Petroleum products
    • Aerosolized household products
    • Correction fluid
ALERT: Pediatric Considerations
  • Prevalent in adolescent age group:
    • Inexpensive “high” with readily available sources
    • Many psychosocial problems
  • May develop chronic neurologic dysfunction
  • Mechanism:
    • Rapidly absorbed by inhalation
    • Readily crosses blood–brain barrier, reaching high concentrations in brain
    • May sensitize myocardium to arrhythmogenic effect of catecholamines
    • Alveolar excretion and liver metabolism
  • Methods of intoxication:
    • Sniffing: Simple inhalation of substance directly from container
    • Huffing: Vapors inhaled through cloth saturated with substance
    • Bagging: Vapors inhaled from bag containing substance
  • Toxic range:
    • 100 ppm: Impairment of psychomotor and perceptual ...

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