The following is an excerpt....
BASICS
Description
- A transplant recipient’s immune response to a graft’s genetically dissimilar antigens resulting in rejection of the transplanted organ
- HLA incompatibility:
- Most common cause of rejection
- Rejection of solid organ transplants
- Antibodies blood group incompatibility:
- Much less of a risk to graft survival than HLA incompatibility
- May result in hyperacute rejection of primarily vascularized grafts, such as kidney and heart
- 3 phases of rejection:
- Hyperacute:
- Occurs in the immediate postoperative period
- Antibody reaction to red cells or HLA antigens
- Endothelial damage
- Platelets accumulate, thrombi develop, and tissue necrosis occurs.
- Rare with careful donor–recipient matching
- Acute:
- Usually occurs within the 1st months after transplantation but may happen at any time if immunosuppressant medication is stopped
- T cell ...
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