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Spectrum of diseases with different clinical significance: It is a histological diagnosis: Accumulation of large fat droplets in the hepatocytes (macrovescicular steatosis) in absence of excessive alcohol consumption

• Patients are asymptomatic
• Only patients with abnormal LFTs during routine testing come to medical attention
• Viral etiology, alcohol abuse and other causes of liver disease must be ruled out
• NAFLD
  • Includes simple fatty liver, NASH and cryptogenic cirrhosis with fatty liver
  • Fat in the liver >5–10% by weight
  • Compatible imaging studies and biopsy
• NASH
  • Subset of NAFLD that may progress to cirrhosis
  • Histology: Fat, necroinflammatory changes and hepatocellular injury (steatohepatitis)
• Cryptogenic cirrhosis: Fatty liver disease most common cause of cryptogenic cirrhosis
• Natural history
  • Natural history of the disease is ...

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