The following is an excerpt....
BASICS
Description
Primary infection of the urinary tract is common with Candida, but uncommon with other fungi. When other fungal infections are found in the GU tract, systemic disease is assumed.
Risk Factors
- Urinary tract drainage catheter
- Prior antibiotics
- Diabetes/glucosuria
- Urinary tract pathology
- Malignancy
- Increased age
- Neonates
- Female sex
- Prior surgical procedures
General Prevention
- Remove unnecessary catheters/tubes
- Narrow antibiotic coverage
- Improve nutritional status
- Control hyperglycemia
Pathophysiology
- Funguria to fungemia:
- Can occur with obstruction, reflux, or instrumentation
- Fungemia to funguria:
- Disseminated disease seeds GU tract
- Multiple microabscesses develop in the renal cortex, with subsequent penetration into the glomeruli and shedding into the urine from the proximal tubules.
Associated Conditions
- Immunocompromised state:
- Anatomic GU abnormalities:
- Strictures
- Prostatic hypertrophy ...
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