The following is an excerpt....
BASICS
Description
MSK is characterized by ectatic or dilated collecting ducts and associated cysts and diverticulas that give the appearance of a paint brush on IVU.
Epidemiology
- Identified in 1 in 200 IVUs
- Estimated at 1 in 5,000–1 in 20,000 in the general population
- Among stone formers, the incidence of MSK is 12–21%, with a female predilection. (1)[B]
Risk Factors
Genetics
Most cases occur sporadically:
- Few cases of autosomal dominant or autosomal recessive inheritance
- Has been reported in association with hemihypertrophy, Beckwith-Wiedemann syndrome, Ehlers-Danlos syndrome
Pathophysiology
- Dilated collecting ducts and small cysts
- Dilated ducts and cysts may be filled with calcium apatite
- No associated cysts in other organs
Associated Conditions
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