The following is an excerpt....
BASICS
Excess secretion of growth hormone results in the clinical syndrome known as acromegaly. This is an endocrine condition that develops insidiously over decades.
Epidemiology
Patients with the condition usually present between the ages of 40 and 45. However, diagnosis is usually delayed 7–10 years after the onset of symptoms (1). Children and adolescents who have excess growth hormone before the epiphyseal growth plates are fused can develop pituitary gigantism.
Incidence
3 cases per 1 million persons per year (1)
Prevalence
60 per million (1)
Risk Factors
The most common cause is a growth hormone-secreting adenoma of the anterior pituitary or somatotroph. More than 90% of acromegaly patients have such a lesion.
Genetics
- The genetics of this disorder ...
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