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Prostatic Intraepithelial Neoplasia (PIN) Updated 4/2010

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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • General Prevention
  • Pathophysiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Complementary and Alternative Medicine

Ongoing Care

  • Complications
  • Follow-Up Recommendations
The following is an excerpt....
BASICS
Description
  • Characterized by architecturally benign prostatic acini or ducts lined by cytologically atypical cells confined within the epithelium
  • It is sub-classified as low-grade PIN (LGPIN) and high-grade PIN (HGPIN).
  • LGPIN was formerly referred as PIN 1 and HGPIN as PIN 2 and 3.
  • Many pathologists are no longer reporting the presence of low-grade PIN as the significance is not clear and should not be commented on in diagnostic reports.
  • Men with LGPIN diagnosed on needle biopsy are at no more risk of having adenocarcinoma on repeat biopsy than are men with a benign biopsy.
  • Literature written before 1989 described PIN as intraductal hyperplasia, hyperplasia with malignant change, large acinar atypical hyperplasia, marked atypia, ductal-acinar ...

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