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Hodgkin Disease Updated 3/2011

Jennifer Gao, MD, Fred Schiffman, MD
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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • Etiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Additional Treatment

Ongoing Care

  • Follow-Up Recommendations
  • Patient Education
  • Prognosis
  • Complications
The following is an excerpt....
BASICS

Description
  • Historical background:
    • Described in 1832 by Thomas Hodgkin in "On Some Morbid Appearance of the Absorbent Glands and Spleen"
    • First neoplasm defined by cytological grounds based on presence of Reed-Sternberg cells
    • First clinically staged neoplastic disease
    • First neoplasm treated with chemotherapy and/or radiotherapy
  • Neoplastic Reed-Sternberg (RS) cells of monoclonal lymphoid B-cell origin within inflammatory background of lymphocytes (T-helper type 2 and regulatory T-cells), eosinophils, histiocytes, and plasma cells (1)
  • 2 subtypes: Classical Hodgkin lymphoma (CHL, 95% of cases) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL, 5% of cases) (1):
    • NLPHL: Predominantly B-cells, neoplastic LH cells with multilobulated nuclei, small nucleoli, and popcornlike appearance
    • Classical Hodgkin lymphoma is further subdivided based on ...

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