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Myeloproliferative Neoplasms Updated 3/2011

Javed M. Gilani, MD, Omar A. Khan, MD, MHS
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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • Pathophysiology
  • Etiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Additional Treatment
  • Surgery
  • In-patient Considerations

Ongoing Care

  • Follow-Up Recommendations
  • Prognosis
  • Complications
The following is an excerpt....
BASICS

Description

Myeloproliferative disorders have been assigned the nomenclature of myeloproliferative neoplasms (MPNs) under the 2008 World Health Organization (WHO) guidelines (1). This classification includes in the MPNs the “classic” conditions chronic myelogenous leukemia ([CML], which is positive for BCR-ABL [Philadelphia (Ph) chromosome]); polycythemia vera (PV); essential thrombocythemia (ET); and primary myelofibrosis (PMF). The MPNs also now include the “nonclassic” conditions chronic neutrophilic leukemia (CNL), chronic eosinophilic leukemia not otherwise classified (CEL-NOS), systemic mastocytosis (SM), and myeloproliferative neoplasm unclassifiable (MPN-u).

  • With each disorder, the proliferation of a particular cell line tends to dominate. These disorders can mimic one another; CML is the only one readily distinguished by the Ph chromosome.
  • CML: Characterized by splenomegaly and increased granulocytes ...

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