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Zollinger-Ellison Syndrome Updated 3/2011

Douglas S. Parks, MD
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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • General Prevention
  • Etiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Additional Treatment
  • Surgery
  • In-patient Considerations

Ongoing Care

  • Follow-Up Recommendations
  • Diet
  • Patient Education
  • Prognosis
  • Complications
The following is an excerpt....
BASICS

Description
  • A triad of:
    • Markedly elevated gastric acid secretion
    • Peptic ulcer disease
    • A gastrinoma or non-β islet cell tumor of the pancreas or duodenal wall that produces gastrin
  • Gastrinomas (at time of diagnosis) may be single or multiple (1/2–2/3), large or small, benign or malignant (2/3), sporadic (70–75%) or associated with MEN1 (Multiple Endocrine Neoplasia type 1) (25–30%).
  • System(s) affected: Endocrine/Metabolic; GI
  • Synonym(s): Z-E syndrome; Pancreatic ulcerogenic tumor syndrome; Multiple endocrine neoplasia, partial; Ulcerogenic islet cell tumor
Epidemiology

Incidence
  • 1–3/million per year
  • Predominant age: Middle age (30–65 years)
  • Predominant sex: Male > Female (1.3:1)
ALERT: Pediatric Considerations
  • Very aggressive cases have been reported in ...

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