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Abnormal Pap and Cervical Dysplasia Updated 4/2011

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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • General Prevention
  • Pathophysiology

DIAGNOSIS

  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Additional Treatment
  • Surgery

Ongoing Care

  • Follow-Up Recommendations
  • Diet
  • Patient Education
  • Prognosis
  • Complications
The following is an excerpt....
BASICS

Description

Cervical dysplasia: Precancerous epithelial changes in the transformation zone of the uterine cervix almost always associated with human papillomavirus (HPV) infections:

  • Mild dysplasia (cervical intraepithelial neoplasia [CIN] I): Cellular changes are limited to the lower 1/3 of the squamous epithelium.
  • Moderate dysplasia (CIN II): Cellular changes are limited to the lower 2/3 of the squamous epithelium.
  • Severe dysplasia (CIN III or carcinoma in situ): Cellular changes involve the full thickness of the squamous epithelium.
  • Pap smear:
    • Screening test for cervical cellular pathology. In many laboratories, automated cervical screening complements the Pap smear or supersedes it.
    • Abnormal cervical smear results can range from benign cellular changes to suggestion of invasive cancer.
  • System(s) affected: Reproductive

ALERT:
  • Cervical ...

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Figure 21-12 Pap smears. A: Normal. Large, flat cells with small nuclei. B: Dysplasia. Large, dark nuclei indicate damaged DNA; cytoplasmic halo indicates human papillomavirus (HPV) effect. C: Malignant. Compact cells with huge, irregular, dark nuclei indicate malignancy.Credit: Thomas H. McConnell, The Nature Of Disease Pathology for the Health Professions, Philadelphia: Lippincott Williams & Wilkins, 2007