The following is an excerpt....
BASICS
Description
- A condition of intense thirst (polydipsia) and excessive urination (polyuria) owing to the kidneys' inability to conserve water as they filter blood.
- Most commonly, this results from decreased pituitary secretion of vasopressin [central diabetes insipidus (DI)] or failure of response to vasopressin (nephrogenic DI).
- Rarely, DI can be induced by pregnancy (gestational DI)
- System(s) affected: Endocrine/Metabolic
Epidemiology
Incidence
- 1/25,000 persons
- May occur in 18.3% following transsphenoidal microsurgery
- Causes of DI:
- 30% idiopathic
- 25% brain tumors (malignant or benign)
- 16% head trauma
- 20% after cranial surgery
Prevalence
- Vasopressin deficiency may occur at any age.
- Nephrogenic DI is usually manifest in infancy.
- Nephrogenic DI is encountered in males more commonly, reflecting its X-linked mode ...
You must be logged in to fully access this content.
Sign up for a 30-Day Free Trial
Sign up for a 30-Day FREE Trial now and receive access to all content.
Have a book code?
Submit your book code to create your
FREE standard account.