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Disseminated Intravascular Coagulation (DIC) Updated 4/2011

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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • General Prevention
  • Pathophysiology
  • Etiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Surgery
  • In-patient Considerations

Ongoing Care

  • Follow-Up Recommendations
  • Prognosis
  • Complications
The following is an excerpt....
BASICS
Description
  • Acquired syndrome characterized by diffuse activation of intravascular coagulation arising from different causes. It can originate from and cause damage to the microvasculature, which, if sufficiently severe, can produce organ dysfunction.
  • Occurring in complications of obstetrics (eg, abruptio placentae, fetus retention, amniotic fluid embolism), infection (especially gram-negative), malignancy (uncontrolled, metastatic tumor or leukemia), trauma, and other severe illnesses
  • System(s) affected: Hematologic/Lymphatic/Immunologic
  • Synonym(s): Consumptive coagulopathy; DIC
Epidemiology
Incidence

Unknown

Prevalence
  • Predominant age: None
  • Predominant sex: Male = Female
Risk Factors

See Etiology

General Prevention

Aggressive interventions aimed at early treatment of the underlying clinical conditions

Pathophysiology
  • Systemic formation of fibrin is the result of the simultaneous coexistence of:
    • Increased thrombin generation via tissue factor/factor ...

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