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Endometrial Cancer and Uterine Sarcoma Updated 4/2011

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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • General Prevention
  • Pathophysiology
  • Etiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Additional Treatment
  • Surgery
  • In-patient Considerations

Ongoing Care

  • Follow-Up Recommendations
  • Diet
  • Patient Education
  • Prognosis
  • Complications
The following is an excerpt....
BASICS
Description
  • Endometrial cancer: Malignancy of the endometrial lining of the uterus
    • Two types
      • I: estrogen dependent, lower grade, better prognosis
      • II: estrogen independent, higher grade, more aggressive
  • Cell types: Adenocarcinoma, adenosquamous (malignant squamous elements), clear cell, and papillary serous
  • Sarcomas: Malignancy of the uterine mesenchyme and mixed tumors:
    • Mixed müllerian sarcoma (carcinosarcoma): Heterologous sarcoma elements are not native to the müllerian system (e.g., cartilage or bone); homologous sarcoma elements are native to the müllerian system.
    • Endometrial stromal sarcoma develops from the stromal component of the endometrium.
    • Leiomyosarcoma develops in the myometrium or rarely in a myoma (fibroid).
    • Poorer prognosis
  • Predominant age:
    • Endometrial cancer: The majority are postmenopausal
      • Median age: 66 years old
    • Sarcomas: Age 40–69 years old ...

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Formation of the uterus and vagina. A. 9 weeks. Note the disappearance of the uterine septum. B. At the end of the third month. Note the tissue of the sinovaginal bulbs. C. Newborn. The fornices and the upper portion of the vagina are formed by vacuolization of the paramesonephric tissue, and the lower protion of the vagina is formed by vacuolization of the sinovaginal bulbs.Credit: Sadler T, PhD. Langman's Medical Embryology, Ninth Edition Image Bank. Baltimore: Lippincott Williams & Wilkins, 2003.
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