The following is an excerpt....
BASICS
Description
- Factor V Leiden is a genetic disease that is the most common hereditary cause of venous thrombosis. It leads to resistance to activated protein C.
- System(s) affected: Cardiovascular; Gastrointestinal; Hemic/Lymphatic/Immunologic; Nervous; Pulmonary; Reproductive
- Synonym(s): Factor V Leiden thrombophilia; factor V Leiden mutation
ALERT:
Pediatric Considerations
- Increased thrombosis risk in patients with factor V Leiden
ALERT:
Pregnancy Considerations
- Heterozygous patients are not at increased risk for thromboembolism or fetal loss.
Epidemiology
- Predominant age: Thrombosis typically occurs after the 2nd decade.
- Predominant sex: Male = Female
Prevalence
- ~3–12% of Caucasions are affected:
- The mutation is rare in other ethnic groups.
- ~15–20% of patients who present with thrombosis have factor V Leiden.
Risk Factors
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