The following is an excerpt....
BASICS
Description
Hypereosinophilic syndrome (HES): A heterogeneous group of chronically high eosinophil states characterized by
- A persistently elevated eosinophil count >1,500 cells/μL for at least 6 months
- Eosinophil-induced end-organ damage
- Exclusion of other causes (e.g., parasitic infection, allergy, malignancy, collagen-vascular disease)
- There are several patient subsets within HES.
- FIP1L1/PDGFRα-associated (F/P+) HES: Myeloproliferative HES, chronic eosinophilic leukemia (CEL)
- F/P– HES:
- Lymphocytic HES (L-HES): CD3-/CD4+ T-lymphocytes produce IL-5
- Organ-restricted disease, e.g., eosinophilic esophagitis
- Idiopathic HES
- System(s) affected: Hematologic; Cardiac; Cutaneous; Pulmonary; Nerologic; GI; Rheumatologic; Ocular
- Synonym(s): Disseminated eosinophilic collagen disease; Löeffler’s fibroplastic endocarditis with eosinophilia (not currently used)
Epidemiology
A rare condition, typically ...
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