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Hypokalemic Periodic Paralysis Updated 4/2011

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BASICS

  • Description
  • Epidemiology
  • Risk Factors
  • General Prevention
  • Pathophysiology
  • Etiology
  • Associated Conditions

DIAGNOSIS

  • Signs and Symptoms
  • Tests
  • Differential Diagnosis

TREATMENT

  • Medication (Drugs)
  • Additional Treatment
  • In-patient Considerations

Ongoing Care

  • Follow-Up Recommendations
  • Diet
  • Patient Education
  • Prognosis
  • Complications
The following is an excerpt....
BASICS
Description
  • Hypokalemic periodic paralysis (HPP) is a channelopathy characterized by episodic skeletal muscle weakness in the setting of a transient decrease in serum potassium (K) levels (1,2). There are 2 forms:
    • Familial hypokalemic periodic paralysis (FHPP), classified as type 1 or type 2 (see Etiology)
    • Hypokalemic periodic paralysis with thyrotoxicosis (thyrotoxic hypokalemic periodic paralysis [THPP])
  • System(s) affected: Endocrine/Metabolic; Musculoskeletal; Nervous
  • Synonym(s): Paroxysmal myoplegia
Epidemiology
  • Predominant age: Onset of disease in late childhood or adolescence (FHPP), early adulthood (THPP). Onset >35 years of age is extremely rare (1,2).
  • Age of onset depends on type of genetic mutation; earlier for type 1 FHPP by an average of 6 years (3).
  • Predominant sex: FHPP, Male > Female (3 ...

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