The following is an excerpt....
BASICS
Description
- Most common functional (insulin-producing) tumor of the pancreas
- Tumors of the pancreatic β cells of the islets of Langerhans; pancreatic β cells secrete both insulin and C-peptide.
- Usually very small, with 90% < 2 cm; suspect malignant insulinoma if tumor > 4 cm (1)[B]
- Usually single and benign; only 10–15% malignant; only 10% multiple tumors
- The malignant potential is not as clinically important as the functional ability to secrete insulin, which leads to symptomatic hypoglycemia.
- Hypoglycemic episodes are irregular, recurrent, and tend to increase in frequency and severity over time.
- Synonym(s): β-Cell tumor, β-Cell adenoma, Nesidioblastoma
Epidemiology
Incidence
- 1/1.25 million annually
- Predominant age:
- Rare: < 20 years old
- 20% of patients are adults < 40 years of age.
- 40% of patients are 40–60 years of age ...
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