The following is an excerpt....
BASICS
Description
- Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by clonal proliferation of myeloid precursors in the bone marrow with continuing differentiation into mature granulocytes.
- Hallmark of CML is Philadelphia chromosome [translocation t(9;22)]
- Natural history of the disease evolves in 3 clinical phases: A chronic phase, an accelerated phase, and blast phase or crisis (transformation to acute leukemia)
Epidemiology
Incidence
- 1.6 cases/100,000 persons per year
- Predominant age: 50–60 years
- Predominant sex: Male > Female (1.3:1)
Prevalence
Accounts for 15–20% of adult leukemias
Risk Factors
Ionizing radiation exposure (uncommon)
Genetics
Acquired genomic changes
General Prevention
None currently identified
Pathophysiology
Philadelphia chromosome is a balanced translocation between BCR (on chromosome 22) and ...
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