The following is an excerpt....
BASICS
Description
- Iatrogenic physiologic complication of controlled ovarian hyperstimulation (most often related to treatment for infertility)
- Results in ovarian enlargement, increased vascular permeability with resulting 3rd-space loss and intravascular fluid depletion, electrolyte imbalance, hemoconcentration, and ascites
- Classification of OHSS is based on clinical symptoms and ultrasound findings.
- Mild: Abdominal distension and discomfort
- Moderate: Abdominal distension, enlarged ovaries (8–10 cm3) and ascites on ultrasound (largest pocket <3 cm)
- Severe: Clinical evidence of ascites and/or hydrothorax, hemoconcentration >45%
- Critical: hemoconcentration >55%, creatinine clearance <50 mL/min, renal failure, thromboembolism, ARDS
- Symptoms of OHSS may occur early (within 10 days of hCG administration) or late (more than 10 days after hCG administration). Late OHSS is usually associated with a pregnancy and may often be more severe.
Epidemiology
Incidence ...
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