The following is an excerpt....
BASICS
- Chronic inflammatory disorder characterized by lymphocytic infiltrates in exocrine organs
- Typically presents with diminished salivary and lacrimal gland function, manifested as sicca symptoms such as:
- Dry eyes, dry mouth, and enlargement of the parotid glands
- Extraglandular symptoms may also be present, such as arthralgia, arthritis, Raynaud phenomenon, myalgia, pulmonary disease, GI disease, leukopenia, anemia, lymphadenopathy, neuropathy, vasculitis, renal tubular acidosis, and lymphoma
- Primary Sjögren: Not associated with other diseases
- Secondary Sjögren: Complication of other rheumatologic conditions, most commonly rheumatoid arthritis
Epidemiology
Incidence
- Depending on the study, annual incidence is about 4/100,000–4.8% of population. Variability is likely due to the different criteria used in diagnosis.
- People of all races are affected.
- Predominant sex: Female > Male (9 ...
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